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Even natural substances can interfere. When relying on our forward-looking statements to make decisions with respect to the Company, investors and others should carefully consider the foregoing factors and other uncertainties and potential events. In particular, the 589 patent discloses formulations where the acetaminophen-to-tramadol ratio falls within the ratio range claimed in the 221 patent. When all these steps are completed, an approval announcement could be made sometime in August, Howard-Tripp said. Be careful if you drive or do anything that requires you to be awake and alert.